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Global collaborative partnerships accelerate efforts to bridge the research gap, particularly in the areas of prevention and implementation and knowledge translation, to improve cancer outcomes worldwide. Countries and world regions need cancer research tailored to their unique disease burden and knowledge gaps to improve population health. Knowledge created in cancer1

Southern, Eastern, and Southeast Asia are some of the most densely populated regions globally, with over 4.3 billion people (55% of the world population). The region contributes 49% of all new cancer cases (9.2 million) and 53% of cancer deaths (5.1 million) worldwide each year. China and India combined account1

Liver cancer is the sixth most frequently occurring cancer in the world, but due to the poor prognosis associated with the disease, it is the third largest contributor to cancer mortality, with an estimated 870,000 cases and 760,000 deaths in 2022 (Map 18.1).

Each country has opportunities to prevent and control cancer through resource-stratified evidence-based interventions across the entire cancer care continuum, from risk factor prevention, early detection and timely diagnosis, to quality treatment, survivorship, palliative care, and end-of-life care (Figure 32.1).

In Europe, there are an estimated 4.1 million new cancer cases and almost 2 million cancer deaths each year. Cancers of the female breast, colorectum, lung, and prostate are the most common cancers, representing half of the overall cancer burden in the continent (Figure 27.1).

There are an estimated 19 million new cancer cases and 9.7 million cancer deaths (excluding non-melanoma skin cancer) worldwide each year. Over half of the cases (9.7 million) and 56% of the deaths (5.4 million) occur in Asia (Figure 22.1), where 60% of the global population (4.6 billion) reside. Europe1

Northern Africa, Central and West Asia is a diverse region characterized by relatively low but increasing cancer incidence rates. Breast cancer is the most common cancer in both sexes combined in all countries but Egypt (liver cancer), Kyrgyzstan and Tajikistan (stomach cancer), and Azerbaijan, Armenia, Tunisia, Türkiye (lung cancer) (Map1

People are living longer after a cancer diagnosis due to advances in early detection and treatment. There are close to 54 million people worldwide who are currently diagnosed with a cancer diagnosis within five years (Figure 31.1).

Ultraviolet radiation (UVR) is the principal cause of common skin cancers: keratinocyte cancers (basal cell and squamous cell carcinomas, referred to as non-melanoma skin cancer in the remaining chapters) and cutaneous melanomas. Each year, more than 332,000 new cases of melanoma occur globally, resulting in more than 59,000 deaths. It1

Editors Ahmedin Jemal, DVM, PhD, American Cancer Society Hyuna Sung, PhD, American Cancer Society Kieran Kelly, MPH, American Cancer Society Isabelle Soerjomataram, MD, PhD, International Agency for Research on Cancer Freddie Bray, MSc, PhD, International Agency for Research on Cancer