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In Europe, there are an estimated 4.1 million new cancer cases and almost 2 million cancer deaths each year. Cancers of the female breast, colorectum, lung, and prostate are the most common cancers, representing half of the overall cancer burden in the continent (Figure 27.1).

Cancer is the leading cause of premature death in North America. An estimated 2.1 million new cancer cases and 701,000 cancer deaths occur in North America each year. The region contributes almost twice the proportion of cases compared to deaths globally (13% versus 7%) in large part because of high1

There are an estimated 19 million new cancer cases and 9.7 million cancer deaths (excluding non-melanoma skin cancer) worldwide each year. Over half of the cases (9.7 million) and 56% of the deaths (5.4 million) occur in Asia (Figure 22.1), where 60% of the global population (4.6 billion) reside. Europe1

While infections (bacteria, viruses, parasites) are responsible for an estimated 12% of new cancer cases annually worldwide, they cause more than one-quarter of all cancers in many low-income countries in Africa and Asia (Map 5.1).

Ultraviolet radiation (UVR) is the principal cause of common skin cancers: keratinocyte cancers (basal cell and squamous cell carcinomas, referred to as non-melanoma skin cancer in the remaining chapters) and cutaneous melanomas. Each year, more than 332,000 new cases of melanoma occur globally, resulting in more than 59,000 deaths. It1

Liver cancer is the sixth most frequently occurring cancer in the world, but due to the poor prognosis associated with the disease, it is the third largest contributor to cancer mortality, with an estimated 870,000 cases and 760,000 deaths in 2022 (Map 18.1).

Today, breast cancer is the most commonly diagnosed cancer (27% of all cancer cases) and the leading cause of cancer death (16% of all cancer deaths) in women globally, ranking the cancer first in 158 countries for incidence and 111 countries for mortality (see Overview of Geographic Diversity). While incidence1

Lung cancer is the most commonly diagnosed cancer and the leading cause of cancer death worldwide, with about 2.5 million new cases and 1.8 million deaths in 2022. Overall rates are twice as high in men than women. The highest incidence and mortality rates in both sexes are found in1

The Latin America and the Caribbean (LAC) region has doubled in population size over the last half-century to 665 million inhabitants today. About 1.5 million new cancer cases and 741,000 cancer deaths, excluding non-melanoma skin cancers, are estimated to occur in the LAC region in 2022. The five most common1