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Liver cancer is the sixth most frequently occurring cancer in the world, but due to the poor prognosis associated with the disease, it is the third largest contributor to cancer mortality, with an estimated 870,000 cases and 760,000 deaths in 2022 (Map 18.1).

Today, breast cancer is the most commonly diagnosed cancer (27% of all cancer cases) and the leading cause of cancer death (16% of all cancer deaths) in women globally, ranking the cancer first in 158 countries for incidence and 111 countries for mortality (see Overview of Geographic Diversity). While incidence1

Population-based cancer registries (PBCRs) are an essential foundation for the development and monitoring of national cancer-control plans, informing the planning of cancer services, and assessing the effectiveness of cancer-care delivery through benchmarking survival in different populations. PBCRs represent a continual system of data collection, storage, validation, and analysis, with the1

There are an estimated 19 million new cancer cases and 9.7 million cancer deaths (excluding non-melanoma skin cancer) worldwide each year. Over half of the cases (9.7 million) and 56% of the deaths (5.4 million) occur in Asia (Figure 22.1), where 60% of the global population (4.6 billion) reside. Europe1

Cancer is now a major public health problem in sub-Saharan Africa, with the disease among the three leading causes of premature death (ages 30-69) in almost all countries in the region. About 820,000 new cancer cases and 550,000 deaths were estimated to have occurred in 2022 in sub-Saharan Africa. For1

Lung cancer is the most commonly diagnosed cancer and the leading cause of cancer death worldwide, with about 2.5 million new cases and 1.8 million deaths in 2022. Overall rates are twice as high in men than women. The highest incidence and mortality rates in both sexes are found in1

Cancer is the leading cause of premature death in North America. An estimated 2.1 million new cancer cases and 701,000 cancer deaths occur in North America each year. The region contributes almost twice the proportion of cases compared to deaths globally (13% versus 7%) in large part because of high1

In Europe, there are an estimated 4.1 million new cancer cases and almost 2 million cancer deaths each year. Cancers of the female breast, colorectum, lung, and prostate are the most common cancers, representing half of the overall cancer burden in the continent (Figure 27.1).

People are living longer after a cancer diagnosis due to advances in early detection and treatment. There are close to 54 million people worldwide who are currently diagnosed with a cancer diagnosis within five years (Figure 31.1).

While infections (bacteria, viruses, parasites) are responsible for an estimated 12% of new cancer cases annually worldwide, they cause more than one-quarter of all cancers in many low-income countries in Africa and Asia (Map 5.1).