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This World Wide Web site with its home page in the domain “cancer.org” (the “Website”) is a complimentary information service offered by the American Cancer Society, Inc. (“ACS”) at no charge to users of the World Wide Web, with the express condition that these users agree to be bound by1

The IARC Monographs identify the causes of human cancer. Sometimes called the World Health Organization’s “Encyclopedia of Carcinogens,” the IARC Monographs are systematic evaluations of the strength of evidence that an agent can cause cancer in humans. Since the program’s inception in 1971, over 1,040 agents have been evaluated, including1

Cancer remains a stark example of the deep inequities in health care faced by Indigenous communities. The United Nations reports that over 476 million Indigenous people reside in over 90 countries across the globe, representing 6.2% of the world’s total population. Despite being a numerical minority worldwide, Indigenous people contribute1

Modifiable risk factors cause a large proportion of cancer cases and deaths. A recent study shows that an estimated 40% of all cancer cases and 44% of cancer deaths in the United States are attributable to a combination of modifiable risk factors, including tobacco use, excess body fatness, and alcohol1

Tobacco products cause at least 17 forms of cancer, and are collectively responsible for over 2 million cancer deaths per year (Figure 4.1).

The continuing and escalating global fight against cancer demands new tools and the latest available data and trends. The Cancer Atlas website and The Cancer Atlas, Fourth Edition book – produced by the American Cancer Society and the International Agency for Research on Cancer – provide a comprehensive global overview1

There are two approaches to early detection – screening and early diagnosis. Screening aims to detect cancers or pre-cancerous lesions in otherwise healthy and asymptomatic individuals, whereas early diagnosis identifies symptomatic cancers at the earliest possible stage (Figure 36.1).

Reproductive and hormonal factors, both endogenous (naturally synthesized in the body) and exogenous (man-made), play important roles in the development of common cancers, including breast, endometrial, ovarian, and cervical cancer, with the strength and direction of these associations varying by cancer types (Figure 9.1). Increased access to higher education, evolving1